LabLogic LIMS ADME Solutions

Application/Technical Notes

β-RAM/RHPLC

• Development of the Next Generation of On-line Radiochromatography Detectors
  T. Deakin and L. F. Thompson, Department of Physics and Astronomy, The University of Sheffield, and J. K. Clapham and R. A. Brown, LabLogic Systems Ltd.
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• Evaluation of Active Counting Mode option in LabLogic β-RAM Model 5 and Laura software
  J. Attwood and B. O-Brien, AstraZeneca R&D Charnwood, and H. W. Loaring and A. Williams, LabLogic Systems Ltd.
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• Use of specific radiolabelled metabolite standards in the optimization of drug metabolising enzyme assays
  Guy Webber, Richard Cole, Vicky Pope, Stephen Hollis, Serge D'Hainaut, Grant Johnston and Stuart Wood, BioDynamics Research Ltd.
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• Continuous-Flow measurment of radioactivity in HPLC eluates
  Edward Rapkin Ph.D.
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• Microsomal Metabolism of the 5-Lipoxygenase Inhibitor L-739,010: Evidence of Furan Bioactivation
  Kanyin E. Zhang, Jeanne A. Naue, Byron Arison, Kamlesh P. Vyas
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• New Radio-HPLC detector solves old problem
  Edward Rapkin, Ph.D.
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• "Comparison of heterogeneous and homogeneous radioactivity flow detectors for simultaneous profiling and LC-MS/MS characterization of metabolites"
  Egnash, Laura A. and Ramanathan, Ragu,, Journal of Pharmaceutical and Biomedical Analysis, 2002, pp. 271-284.
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• "The Disposition of Gemifloxacin, a New Fluoroquinolone Antibiotic, in Rats and Dogs "
  J. V. Ramji, N. E. Austin, G. W. Boyle, M. H. Chalker, G. Duncan, A. J. Fairless, F. J. Hollis, D. F. McDonnell, T. J. Musick, and P. C. Shardlow. The American Society for Pharmacology and Experimental Therapeutics, Vol. 29, Issue 4, Part 1, 435-442, April 2001.
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• "Disposition and Metabolism of 2-(2"(1",3"-Dioxolan-2-Yl)-2-Methyl-4-(2'-Oxopyrrolidin-l -Yl)-6-Nitro-2h-l-Benzopyran(skp-450) in Rats"
  Baek, Minsun, Chung. Hak Soon, Kim, Yunje, and Kim, Dong-Hyun. Drug Metabolism and Disposition Vol. 27. pp. 510-516.
• "LC-MS/MS Characterization and comparison of metabolites formed from structural analogs. Cl-ABC, PD 123, and PD 456"
  Egnash, Laura A., Lapham, Kimberly, and Ramanathan, Ragu, Pfizer Global. Research and Development, 2001.
• "Sequential Injection Separation System with Stopped-Flow Radiometric Detection for Automated Analysis of 99Te in Nuclear Waste"
  Egorov,Oleg, O'Hara, Matthew J., Ruzicka, Jaromir and Grate, Jay W.,, Analytical Chemistry. March 1, 1998, Vol. 70, No. 5, pp. 977-984.
• "An efficient Synthesis of Carbon-14 Labelled Vigabatrin", Journal of Labelled Compounds and Radiopharmaceuticals"
  Gill, Harpal S.,, VOL XXXVI. No. 5. 1994, pp. 425-430.
• "Anaerobic Bioremediation of Benzene under Sulfate-Reducing Conditions in a Petroleum-Contaminated Aquifer"
  Lovely. Derek R. and Anderson, Robert T., Environmental Science & Technology, 2000, Vol. 34, pp. 2261-2266.
• "Basic Guide to the Mechanisms of Antiestrogen Action", Pharmacological Reviews"
  MacGregor, Jennifer I., and Jordan, V.Craig , 1998, Vol. 50, pp. 151-196.
• "Synthesis of Paclitaxel-C3'-14C". Journal of Labelled Compounds and Radiopharmaceuticals"
  Walker. Donald G., Standridge, Robert T., and Swigor, John E., , 1994, Vol. XXXVI, No. 5, pp. 479-492.
• "Beta -Particle Detection in HPLC by Flow-Through Monitoring vs. Liquid Scintillation Counting". Journal of Liquid Chromatography"
  Rapkin. Edward, , 1993, 16(8), pp. 1769-1781.
• "A Rapid Method for Determination of Beta-Emitting Radionuclides in Aqueous Samples"
  Reboul, Scott H., and Fjeld, Robert A. , Radioactivity and Radiochemistry. 1994, Vol. 5, No. 3, pp. 42 - 49.
• "Potential Effects of Surface Water Components on Actinide Determinations Conducted by Ion Chromatography"
  Reboul, Scott H., and Fjeld, Robert A., Health Physics, April 1995, Vol. 68, No. 4, pp. 585-589.
• Evaluation of the New SoFie System for Detection and Analysis of Low Level Radio Labelled Compounds On-line with Radio Flow Analyzers
  Keith A. Hall and Huw W. Loaring, Drug Metabolism Reviews, 2008, Vol 40, p.118.
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Mini Scan

• A comparison of techniques for analyzing ⁹⁰Y-Zevalin thin-layer chromatographic plates
  Lesley M. O'Brien, Clinton C. Waight and Alistair M. Millar. Nuclear Medicine Communications 2005, 26: 163 - 166
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• Validation of the BioScan Mini-Scan thin-layer radiochromatogram scanner and associated LabLogic Laura software for the QA of ^99mTc radiopharmaceuticals
  Lynn A Beattie, Lesley M O’Brien, Alistair M Millar, Radiopharmacy, The Royal Infirmary of Edinburgh
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• Validation of the use of Sodium Chloride Injection from Braun Mini-Plasco Connect ampoules in the preparation of ^99mTc-MAG3 Injection
  Fiona Craig, Lynn A Beattie, Lesley M O’Brien, Alistair M Millar. Radiopharmacy, The Royal Infirmary of Edinburgh
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• The effect of reconstitution volume on the rate of labelling and radiochemical purity of ^99mTc-Mebrofenin
  Lesley M O’Brien, Lynn A Beattie, Alistair M Millar, Radiopharmacy, The Royal Infirmary of Edinburgh
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AR 2000

• Imaging scanners for radiolabelled thin-layer chromatography
  C.O. Rock, S. Jackowski and S.D. Shulman. BioChromatography, 1988, Vol 3, No. 3, p127
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Flow Counting

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• Improved Liquid Scintillator For Radio-Flow Measurement. A comparison of IN-FLOW 2:1 with currently available cocktails. <%end if%>
• Background Considerations in Radio Flow-through Detectors
• Background In Flow-Through Detection: An Update
• The Best Liquid Scintillator For Continuous-Flow Measurement
• Continuous-Flow Measurement of Radioactivity in HPLC Eluates

Liquid Scintillation Counting

• Understanding Pulse-height Analysis in a β Counter

Radiosynthesis

• Modern Tritium Handling in the Synthesis Laboratory

Debra

• Plasma Pharmacokinetics and Tissue Distribution of a N-Pyrrolo- [1,2-c]Imidazolylphenyl Sulfonamide in Rats
  Mehran F. Moghaddam, Matthew S. Bogdanffy, Alethia Brown, Kim Ford, and Lamaat Shalaby. Nutrition and Health (M.F.M.). Drug Metabolism and Disposition, Vol. 30, Issue 1, 47-54, January 2002
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• Pharmacokinetics, Metabolism, and Excretion of Linezolid following an Oral Dose of [14C]Linezolid to Healthy Human Subjects
  J. G. Slatter, D. J. Stalker, K. L. Feenstra, I. R. Welshman, J. B. Bruss, J. P. Sams, M. G. Johnson, P. E. Sanders, M. J. Hauer, P. E. Fagerness, R. P. Stryd, G. W. Peng, and E. M. Shobe. Drug Metabolism and Disposition, Vol. 29, Issue 8, 1136-1145, August 2001
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• Pharmacokinetics, Metabolism, and Excretion of Irinotecan (CPT-11) Following I.V. Infusion of [14C]CPT-11 in Cancer Patients
  John Greg Slatter, Larry J. Schaaf, James P. Sams, Kenneth L. Feenstra, Mark G. Johnson, Paul A. Bombardt, Karen Sue Cathcart, Michael T. Verburg, Laura K. Pearson, Linda D. Compton, Langdon L. Miller, David S. Baker, Caroline V. Pesheck, and Raymond S. Lord, III. Drug Metabolism and Disposition, Vol. 28, Issue 4, 423-433, April 2000
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Laura

• Species Differences in the Disposition of the CCR5 Antagonist, UK-427,857, a New Potential Treatment for HIV
  Don K. Walker, Samantha Abel, Pierre Comby, Gary J. Muirhead, Angus N. R. Nedderman, and Dennis A. Smith. Drug Metabolism and Disposition Fast Forward. First published on January 13, 2005
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• NONLINEAR ORAL PHARMACOKINETICS OF THE ALPHA-ANTAGONIST 4-AMINO-5-(4-FLUOROPHENYL)-6,7-DIMETHOXY-2-[4-(MORPHOLINOCARBONYL)-PERHYDRO-1,4-DIAZEPIN-1-YL]QUINOLINE IN HUMANS: USE OF PRECLINICAL DATA TO RATIONALIZE CLINICAL OBSERVATIONS
  Anthony Harrison, Alison Betts, Katherine Fenner, Kevin Beaumont, Alan Edgington, Sarah Roffey, John Davis, Pierre Comby, and Paul Morgan. Drug Metabolism and Disposition, 32:197-204, 2004
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