Application Notes


Use of "High Sensitivity" Beta-Ram Radio Detector in Active Counting Mod
Nejad H., Singh M., Ta C., Traversa E. APD/ER
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Development of the Next Generation of On-line Radiochromatography Detectors
T. Deakin and L. F. Thompson, Department of Physics and Astronomy, The University of Sheffield, and J. K. Clapham and R. A. Brown, LabLogic Systems Ltd.
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Evaluation Of Active Counting Mode Option In LabLogic RAM Model 5 And Laura Software
J. Attwood and B. O-Brien, AstraZeneca R&D Charnwood, and H. W. Loaring and A. Williams, LabLogic Systems Ltd.
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Use Of Specific Radiolabelled Metabolite Standards In The Optimization Of Drug Metabolising Enzyme Assays
Guy Webber, Richard Cole, Vicky Pope, Stephen Hollis, Serge D'Hainaut, Grant Johnston and Stuart Wood, BioDynamics Research Ltd.
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Continuous Flow Measurement Of Radioactivity In HPLC Eluates
Edward Rapkin Ph.D.

Microsomal Metabolism of the 5-Lipoxygenase Inhibitor L-739,010: Evidence of Furan Bioactivation
Kanyin E. Zhang, Jeanne A. Naue, Byron Arison, Kamlesh P. Vyas
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New Radio HPLC Detector Solves Old Problem
Edward Rapkin, Ph.D.
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"Comparison of heterogeneous and homogeneous radioactivity flow detectors for simultaneous profiling and LC-MS/MS characterization of metabolites"
Egnash, Laura A. and Ramanathan, Ragu,, Journal of Pharmaceutical and Biomedical Analysis, 2002, pp. 271-284.
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"The Disposition of Gemifloxacin, a New Fluoroquinolone Antibiotic, in Rats and Dogs "
J. V. Ramji, N. E. Austin, G. W. Boyle, M. H. Chalker, G. Duncan, A. J. Fairless, F. J. Hollis, D. F. McDonnell, T. J. Musick, and P. C. Shardlow. The American Society for Pharmacology and Experimental Therapeutics, Vol. 29, Issue 4, Part 1, 435-442, April 2001.

"Disposition and Metabolism of 2-(2"(1",3"-Dioxolan-2-Yl)-2-Methyl-4-(2'-Oxopyrrolidin-l -Yl)-6-Nitro-2h-l-Benzopyran(skp-450) in Rats"
Baek, Minsun, Chung. Hak Soon, Kim, Yunje, and Kim, Dong-Hyun. Drug Metabolism and Disposition Vol. 27. pp. 510-516.

"LC-MS/MS Characterization and comparison of metabolites formed from structural analogs. Cl-ABC, PD 123, and PD 456"
Egnash, Laura A., Lapham, Kimberly, and Ramanathan, Ragu, Pfizer Global. Research and Development, 2001.

"Sequential Injection Separation System with Stopped-Flow Radiometric Detection for Automated Analysis of 99Te in Nuclear Waste"
Egorov,Oleg, O'Hara, Matthew J., Ruzicka, Jaromir and Grate, Jay W.,, Analytical Chemistry. March 1, 1998, Vol. 70, No. 5, pp. 977-984.

"An efficient Synthesis of Carbon-14 Labelled Vigabatrin", Journal of Labelled Compounds and Radiopharmaceuticals"
Gill, Harpal S.,, VOL XXXVI. No. 5. 1994, pp. 425-430.

p> "Anaerobic Bioremediation of Benzene under Sulfate-Reducing Conditions in a Petroleum-Contaminated Aquifer"
Lovely. Derek R. and Anderson, Robert T., Environmental Science & Technology, 2000, Vol. 34, pp. 2261-2266.

"Basic Guide to the Mechanisms of Antiestrogen Action", Pharmacological Reviews"
MacGregor, Jennifer I., and Jordan, V.Craig , 1998, Vol. 50, pp. 151-196.

"Synthesis of Paclitaxel-C3'-14C". Journal of Labelled Compounds and Radiopharmaceuticals"
Walker. Donald G., Standridge, Robert T., and Swigor, John E., , 1994, Vol. XXXVI, No. 5, pp. 479-492.

"Beta -Particle Detection in HPLC by Flow-Through Monitoring vs. Liquid Scintillation Counting". Journal of Liquid Chromatography"
Rapkin. Edward, , 1993, 16(8), pp. 1769-1781.

"A Rapid Method for Determination of Beta-Emitting Radionuclides in Aqueous Samples"
Reboul, Scott H., and Fjeld, Robert A. , Radioactivity and Radiochemistry. 1994, Vol. 5, No. 3, pp. 42 - 49.

"Potential Effects of Surface Water Components on Actinide Determinations Conducted by Ion Chromatography"
Reboul, Scott H., and Fjeld, Robert A., Health Physics, April 1995, Vol. 68, No. 4, pp. 585-589.

Evaluation of the new SoFie™ system for detection and analysis of low level radio labelled compounds on-line with radio flow analyzers
Keith A. Hall and Huw W. Loaring, Drug Metabolism Reviews, 2008, Vol 40, p.118.


Evaluation of a commercial radiochromatography module as an arterial blood activity monitor
C M Laymon, D Sashin, J P Carney, J Ruszkiewicz, D Altenburger, C R Becker, B J Lopresti, N S Mason, J M Mountz, J C Price, R Schavey and C A Mathis. Physics in Medicine and Biology 2008, Vol 53, No. 2, p339


Design, Synthesis, and Biological Characterization of a Caspase 3/7 Selective Isatin Labeled with 2-[18F]fluoroethylazide
Graham Smith, Matthias Glaser, Meg Perumal, Quang-De Nguyen, Bo Shan, Erik Årstad, and Eric O. Aboagye. Journal of Medicinal Chemistry 2008, Vol 51 (24), p8057-8067
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Mini Scan

A comparison of techniques for analyzing 90Y-Zevalin thin-layer chromatographic plates
Lesley M. O'Brien, Clinton C. Waight and Alistair M. Millar. Nuclear Medicine Communications 2005, 26: 163 - 166

Validation of the BioScan Mini-Scan thin-layer radiochromatogram scanner and associated LabLogic Laura software for the QA of 99mTc radiopharmaceuticals
Lynn A Beattie, Lesley M O’Brien, Alistair M Millar

Validation of the use of Sodium Chloride Injection from Braun Mini-Plasco Connect ampoules in the preparation of 99mTc-MAG3 Injection
Fiona Craig*, Lynn A Beattie, Lesley M O’Brien, Alistair M Millar

The effect of reconstitution volume on the rate of labelling and radiochemical purity of 99mTc-Mebrofenin
Lesley M O’Brien, Lynn A Beattie, Alistair M Millar

AR 2000

Imaging Scanners For Radiolabelled Thin-layer Chromatography
C.O. Rock, S. Jackowski and S.D. Shulman. BioChromatography, 1988, Vol 3, No. 3, p127


Plasma Pharmacokinetics and Tissue Distribution of a N-Pyrrolo- [1,2-c]Imidazolylphenyl Sulfonamide in Rats
Mehran F. Moghaddam, Matthew S. Bogdanffy, Alethia Brown, Kim Ford, and Lamaat Shalaby. Nutrition and Health (M.F.M.). Drug Metabolism and Disposition, Vol. 30, Issue 1, 47-54, January 2002

Pharmacokinetics, Metabolism, and Excretion of Linezolid following an Oral Dose of [14C]Linezolid to Healthy Human Subjects
J. G. Slatter, D. J. Stalker, K. L. Feenstra, I. R. Welshman, J. B. Bruss, J. P. Sams, M. G. Johnson, P. E. Sanders, M. J. Hauer, P. E. Fagerness, R. P. Stryd , G. W. Peng, and E. M. Shobe. Drug Metabolism and Disposition, Vol. 29, Issue 8, 1136-1145, August 2001

Pharmacokinetics, Metabolism, and Excretion of Irinotecan (CPT-11) Following I.V. Infusion of [14C]CPT-11 in Cancer PatientsThe Best Liquid Scintillator For Continuous-Flow MeasurementBackground Considerations in Radio Flow-through Detectors
John Greg Slatter, Larry J. Schaaf, James P. Sams, Kenneth L. Feenstra, Mark G. Johnson, Paul A. Bombardt, Karen Sue Cathcart, Michael T. Verburg, Laura K. Pearson, Linda D. Compton, Langdon L. Miller, David S. Baker, Caroline V. Pesheck , and Raymond S. Lord, III. Drug Metabolism and Disposition, Vol. 28, Issue 4, 423-433, April 2000

Flow Counting

Improved Liquid Scintillator For Radio-Flow Measurement

Background Considerations in Radio Flow-through Detectors

Background In Flow-Through Detection: An Update

The Best Liquid Scintillator For Continuous-Flow Measurement

Continuous-Flow Measurement of Radioactivity in HPLC Eluates

Liquid Scintillation Counting

 Understanding Pulse-height Analysis in a β Counter


Modern Tritium Handling in the Synthesis Laboratory


Species Differences in the Disposition of the CCR5 Antagonist, UK-427,857, a New Potential Treatment for HIV
Don K. Walker, Samantha Abel, Pierre Comby , Gary J. Muirhead, Angus N. R. Nedderman, and Dennis A. Smith. Drug Metabolism and Disposition Fast Forward. First published on January 13, 2005

Nonlinear oral pharmacokinetics of the alpha-antagonist 4-amino-5-(4-fluorophenyl)-6,7-dimethoxy-2-[4-(morpholinocarbonyl)-perhydro-1,4-diazepin-1-yl]quinoline in humans: use of preclinical data to rationalize clinical observations
Anthony Harrison, Alison Betts, Katherine Fenner, Kevin Beaumont, Alan Edgington, Sarah Roffey, John Davis, Pierre Comby , and Paul Morgan. Drug Metabolism and Disposition, 32:197-204, 2004