Controlling the 68Ge/68Ga elution rate in preparation for the use of 68Ga in PET/CT
12 October 2022
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Using the Hidex AMG to determine radionuclide purity of Gallium-68 from Gallium generators before injection
The Hidex AMG automatic gamma counter has been specifically designed for nuclear medicine applications and delivers accurate Quality Control through Ge/Ga elution ratio measurements using a dedicated software module. This is becoming increasingly relevant due to the current use of Ga-68 DOTATATE and emerging use of 68Ga PSMA.
When 68Ga is obtained from 68Ge/68Ga generators, even minute traces of the long-lived parent (68Ge) remain and increases the radiation dose to patients, because of its long half-life. Radionuclide purity control of 68Ge should result in an impurity level of < 0.001%. Hidex’s Ge/Ga elution software module allows the precise determination of the residual 68Ge content in the 68Ga eluate supplied by the generator.
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The elution rate is calculated automatically from the reference activity supplied by the generator and the activity measured on the counter, taking into account the large differences in half-life between 68Ge and 68Ga. This percentage can be checked and verified over time as part of the QC process and the result is also calculated and presented in activity/volume.
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Find out more
You can learn more about the Hidex AMG and its Ge/Ga elution module by clicking the button below to request a guided demonstration with a product specialist.