The Spec-RAM LC is ideally suited to radiopharmaceuticals with complex decay pathways, where daughter isotopes contribute signals within the parent energy window, such as with ²¹²Pb. The instrument was developed in direct response to industry demand for an effective QC solution for ²¹²Pb radiopharmaceuticals, driven by the therapeutic potential of its alpha-emitting daughter, ²¹²Bi.

The Spec-RAM LC can also be used as a standard gamma spectrometer for measuring the radionuclidic identity and radionuclidic purity of a wide range of isotopes. Alternatively, it can be used as an online HPLC detector for common isotopes such as ^99mTc, ¹⁸F, ⁶⁸Ga, ¹⁷⁷Lu and more.

As part of LabLogic’s ongoing commitment to continuous product development, we are pleased to introduce the Spec-RAM LC+ featuring a bigger detector volume for even greater sensitivity in the same package and footprint as the original Spec-RAM LC.

The Spec-RAM LC+ has even greater efficiency, allowing contributions from ²¹²Bi and ²⁰⁸Tl to be isolated.

The Spec-RAM LC uses a Cadmium Zinc Telluride (CZT) detector. Because of the high atomic numbers of Cd and Te, CZT is highly sensitive to gamma rays and provides an energy resolution (FWHM) of ≤2.5 % compared to traditional scintillator detectors.

CZT detectors operate at ambient temperature without cryogenic cooling.

The Spec-RAM LC is compatible with any HPLC system, including LabLogic’s Logi-CHROM, allowing users to integrate the gamma spectrometer into existing HPLC workflows. Laura Radiopharma is compatible with all components from the world’s leading manufacturers of HPLC systems, providing a single point of control for your instruments.

A range of fixed volume cells including 10, 20, 50, 100 and 200 µL are available. Additional flow cell volumes are available on request.

The Spec-RAM LC was developed specifically in response to a demand from industry for a solution for the Quality Control of ²¹²Pb radiopharmaceuticals because of the therapeutic potential of its alpha-emitting daughter ²¹²Bi.

In the 238 keV energy window, there are contributions from ²¹²Bi, ²⁰⁸Tl, and ²¹²Pb, but for RCP, only the parent ²¹²Pb is measured. This can be particularly difficult to do using a traditional gamma counter because of the daughter gamma rays scattering, creating a signal inside the ²¹²Pb energy window, even when there is no ²¹²Pb present in the HPLC eluant. Only a detector with sufficient resolution and “above scatter” peak integration such as the Spec-RAM LC can effectively discriminate between the 277 keV gamma from ²⁰⁸Tl and the 238 keV gamma from ²¹²Pb.

The Spec-RAM LC enables in-line quantification, providing direct radiochemical purity measurements. This means no more waiting for the decay of short-lived daughters and no more laborious fraction collecting.

The Spec-RAM LC is highly sensitivity thanks to a copper liner that eliminates Compton scattering and a lead shield attenuates background environmental radiation and exposure to the operator. This delivers an excellent signal-to-noise ratio with the detection of low-level peaks at sub kBq levels.

With a diameter of only 24 cm, the Spec-RAM LC is a benchtop instrument that is light enough and small enough to sit on any standard laboratory bench.

Laura Radiopharma has a fully featured audit trail that can be configured to suit the requirements of the user’s site. Response from the user can be a simple as choosing from a predefined list of standard audit reasons or require a unique response depending on the situation and site rules.

Laura Radiopharmacy features multi-level access control, and the system can be configured to have as many levels of access as the user’s site requires. Menu items are then restricted according to the security level of the individual logged in.

Laura Radiopharma supports the use of electronic signatures, and the system can be configured to suit the user sites requirements for electronic data.

Regulatory compliance is an essential feature of Laura Radiopharmacy, built to meet GLP/GMP, FDA 21 CFR part 212 / 11, and EU Annex 11 requirements. Featuring configurable audit trail, electronic signatures, secure data storage in a database environment and multi-level security, Laura Radiopharma can be configured to meet regulatory requirements for data integrity.

Laura Radiopharma can be configured to suit your particular site requirements for security. Usernames and passwords can be controlled relative to the site requirements as can inactivity time outs and all other functions required for a secure system.

Laura Radiopharma’s Nuclide ID function allows users to simultaneously test radionuclidic identification via a half-life measurement and radionuclidic purity using the Spec-RAM CZT. By measuring decay every 1 second at the same time as performing gamma spectrometry on one sample, a decay chain is visualised on screen in real-time, providing dozens of datapoints within minutes to automatically identify radionuclides.

Revolutionising Pb-212 QC

AdvanCell is pioneering Targeted Alpha Therapy, rapidly translating a reliable supply of radiopharmaceuticals using ²¹²Pb to commercial scale. The Australian company has been one of the first adopters of the Spec-RAM LC, using it to supersede fraction collection and gamma counting.

In this video, Chief Scientific Officer Simon Puttick tells us why the burgeoning relationship between AdvanCell and LabLogic is generating increasing excitement for ²¹²Pb radiopharmaceuticals.

You can find out what Simon had to say by watching the video or clicking the button below.

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Instant radiochemical purity analysis

Orano Med is a biotechnology company specialising in the development of new therapies using ²¹²Pb. At this year’s EANM in Barcelona, we sat down with Chief Scientific Officer Julian Torgue to discuss his partnership with LabLogic. Julian spoke about how this new solution for Targeted Alpha Therapies is allowing Orano Med’s Drug Development and Preclinical Unit (DDPU) in Plano, Texas to deliver instant results with greater precision, without having to collect fractions or use a gamma counter.

You can find out what he had to say by clicking the button below or watching our video interview with him.

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Developing theranostic platforms using ²¹²Pb and ²⁰³Pb

LabLogic Field Service Engineers Afzal Yacoob and Timothy Fujihara install the Spec-RAM LC at Perspective Therapeutics.

Perspective Therapeutics is a clinical-stage radiopharmaceutical company that is pioneering innovative treatments for cancers using ²¹²Pb to deliver powerful radiation directly to cancer cells via high-affinity targeting peptides. These radiotherapies are developed as theranostic platforms by incorporating the radiotracer ²⁰³Pb for imaging into the same targeting peptides.