iPHASE MultiSyn

Compact Multisynthesis Radiosynthesiser

The MultiSyn enables the radiochemist to easily synthesise the following theranostic agents with high isotope recovery.

• ¹⁷⁷ Lu-PSMA
• ¹⁷⁷ Lu-DOTATATE
• ¹⁶¹ Tb-PSMA-I&T
• ²²⁵ Ac-PSMA-IT
• ²²⁵ Ac-HA-DOTATATE

¹⁷⁷ Lu Cassette has been tested with up to 100 GBq (2.7 Ci) of starting activity resulting in a >95% uncorrected radiochemical yield.

Easily develop novel methods such as ⁶⁴Cu and ⁶⁷Cu radioisotope radiolabelling with the MultiSyn for both PET imaging and theranostic applications.

Fully automate ⁸⁹Zr monoclonal antibody radiolabelling using the MultiSyn. The typical fully automated synthesis process involves:

1. Automated cartridge conditioning
2. ⁸⁹ Zr Neutralization
3. Radiolabelling
4. Purification using PD-10 cartridge

The hardware cassettes and reagent sets helps avoid cross-contamination and ensures reproducible results. This enables users to effortlessly meet the most stringent Quality Control and GMP-compliance standards.

Hardware cassettes are manufactured in GMP cleanrooms and gamma sterilised. Each comes with a Certificate of Conformance.

The MultiSyn is compatible with all commercial ⁶⁸Ga generators. The synthesizer features a built-in force-limiting syringe drive for generator elution and supports direct use of the generator eluate without pre-purification, as well as cationic or anionic pre-purification methods.

Direct Elution Labelling

The simplest ⁶⁸Ga synthesis method involves direct labelling of the generator's eluate. This method reduces synthesis time and simplifies system setup.

Generator Pre-purification

Certain reactions require reduction of the acid concentration of the generator eluate and/or purification of metal impurities (such as  ⁶⁸Ge) from the eluate to improve reaction conditions.

This is easily accomplished with generator pre-purification and involves trapping the generator eluate into a purification cartridge and subsequent elution to the reactor with a >99% trap and release efficiency of  ⁶⁸Ga.

Multiple Generator Elution

The MultiSyn can be used to elute multiple generators to increase final radiotracer activity. The process is automated with no need to rotate any taps manually.

The MultiSyn has a compact instrument footprint to save critical space in the lab, measuring 23.8 cm (W) x 24 cm (D).

The MultiSyn solid target dissolution expansion module will enable the MultiSyn to be a complete system for the closed-circuit dissolution of coin based solid targets (⁶⁴Cu, ⁸⁹Zr, ⁶⁸Ga) and purification of the dissolved isotope on the MultiSyn's disposable cassette.

Coin-based Solid Target Dissolution

1. MultiSyn pressure tests expansion module's fluidic circuit
2. MultiSyn transfers reagents to expansion module
3. Drop irradiated target into funnel
4. Clamp coin to seal target face
5. Peristaltic pump circulates heated acid to dissolve target

Target Purification Process

1. MultiSyn transfers dissolved target from Expansion Module
2. Cartridge purification of dissolved target on MultiSyn's disposable cassette

For expanded liquid transfer capabilities, which is ideal for transferring small or large volumes with high accuracy.

Modes of operation:

• Constant flow rate, 0-25 mL/min
• Transfer desired volume at desired flow rate
• Forward and reverse flow control

The MultiSyn's PLC (Programmable Logic Controller) electronics are housed in an external enclosure located outside of the hotcell.

This eliminates the possibility of damage to the electronic components due to high radiation fields, thereby significantly increasing system reliability.