New flow cell volume options with the new Beta-RAM 6
27/10/2025
At a glance
> LabLogic’s radio-HPLC flow detector is now available in two models, the IRIS and SC.
> The IRIS uses a dynamic aperture that opens and closes to reveal or obscure the flow cell tubing, providing users with a wide range of cell volumes without having to change the flow cell.
> The new SC – Standard Cell – provides a traditional flow cell configuration with options for liquid mixing or solid scintillator cells.
Horizontal or vertical stacking
Controlled by Laura radiochromatography software, the Beta-RAM 6 is a compliant solution for the detection of low-energy betas such as 3H and 14C. Both models share many standard features that has made the instrument so popular for research and radiochemical purity checks but with new options available for controlling the flow cell volume.
The new Beta-RAM can also be stood vertically to reduce the instrument’s footprint where lab space may be prohibitive, or stacked conventionally in an HPLC system, depending on the user’s preference.
So, what’s the difference between the two models?
Traditional flow cell configurations with the new Standard Cell
The new SC – Standard Cell – provides a traditional flow cell configuration with options for liquid mixing or solid scintillator flow cells such as yttrium silicate and lithium glass. Replaceable flow cells can be easily changed with a range of volumes and types available, including small volume flow cells less than 100 μl for UHPLC applications.
Dynamic cell volumes with the IRIS
The IRIS model provides users with a wide range of flow cell volumes, all available without having to change the flow cell. Developed and patented by LabLogic, the IRIS is a dynamic aperture that opens and closes to reveal or obscure the flow cell tubing. Closing the IRIS replicates a smaller cell volume down to 100 μl delivering sharper peaks and improved resolution. Opening the IRIS will replicate a larger cell up to 500 μl with a longer residence time for improved sensitivity.
The IRIS model also features an integrated liquid manifold for liquid distribution and mixing with scintillation cocktail. The manifold is designed to reduce dead volume to a minimum, ensuring excellent peak shape and resolution.
A customisable radio-HPLC detector
Optional features applicable to both Beta-RAM models include the Radwaste valve, which diverts the outflow to a separate waste line when radioactivity is detected, and the Stop Flow valve, which holds the HPLC under pressure whilst the eluate flow is paused temporarily to increase the residence time of analytes in the flow cell. This allows users to define a fraction time and counting time.
Both models also share many universal features designed to improve sensitivity and counting efficiency such as coincidence counting. Regardless of the model and cell volume chosen, Laura automatically identifies the cell type, allowing for automatic calculation of eluate residence time and other counting units such as CPM and DPM.
Find out more
You can learn more about the new Beta-RAM’s different models by clicking the button below to speak to a product specialist directly and request a guided demonstration.