The worlds leading radio flow detector offers unrivaled sensitivity, resolution and versatility.

With over 30 years of development and used by thousands of researchers worldwide, the Beta-RAM coupled with the industry standard Laura software, leads the way for radiochromatographers. 

Sensitivity

The Beta-RAM offers superb sensitivity with the speed and efficiency of on-line counting. Special functions such as Active Counting Mode and Stop Flow offer the users unrivaled levels of sensitivity and limits of detection.

Resolution

The B-RAM uses low dead volume fittings, tubing and mixing components to ensure the best possible resolution between peaks and to retain peak shape. Specially designed flow cells are also used to keep peak integrity. The B-RAM also supports the latest LC techniques such as UPLC, Fast LC, Rapid resolution LC.

Versatility

The B-RAM range offers the versatility of either homogeneous counting by admixing with liquid scintillator via the accurate built in pump or heterogeneous counting with a range of pre-packed solid scintillator flow cells. This makes the B-RAM the versatile choice whether you are doing the most sensitive low level metabolism work or high activity preperative HPLC work.

Resolution

Resolution is a key factor in assessing the suitability of your chromatographic method. 

The Beta-RAM has been developed to complement the latest separation technologies such as UHPLC, Fast LC, Rapid Resolution LC.

Great care has been taken with choice of fittings and flow cell design to reduce dead volume and therefore maintain peak shape and integrity.

Support for UHPLC®, Rapid Resolution LC, Fast LC

New LC technologies bring new challenges for the radio chromatographer, the new Beta-RAM model meets those challenges.

Low dead volume fittings, tubing and mixing components optimized for low flow rates ensure optimum peak shape and definition.

Specially designed flow cells in volumes ranging from 5ul give superb performance under even the most demanding conditions.

The Beta-RAM range has always offered the lowest background and the model 5 improves this even further.

The Beta-RAM also features sub-second update times to ensure the greatest accuracy with the tightest peaks.

Stop Flow

Stop flow replaces the requirement for time consuming and expensive Liquid Scintillation Counting of low level samples.

By optimizing the counting time in the detector flow cell, the combination of the stop flow option and Laura software allows the radiochemical measurement to be entirely at the threshold and measurement level required by the user.

The stop flow mode allows the user to achieve superb levels of sensitivity without the labor intensive, time consuming process of fraction collecting.

Active Counting Mode

Radio flow detection has traditionally used a variety of static parameters that are applied to the entire run. We are now able to alter the detection characteristics according to a simplified heterodyne model. This allows the system to actively monitor and adjust run conditions in real time, applying the most appropriate settings dynamically.

Standard flow:

 ACM provides unrivalled limits of detection while keeping run duration the same as a conventional run. This gives on-line detection limits previously only achieved off-line; Improved resolution and peak definition.

Using ACM™

Other Features

  • USB Interface for control and data collection
  • Bluetooth link allows control through a pocket digital assistant
  • Improved cell design reduces dead volume
  • Sub-second updates for the greatest accuracy with the tightest peaks
  • Ergonomic design
  • Smallest ever footprint
  • Drip tray and leak detection technology

 Laura

Radiochromatography Data Collection and Analysis Software

Instrument control, digital data collection, analysis and reporting all achieved using the industry standard radiochromatography data system Laura™.

Laura™ has been the recognised industry standard software for radiochromatography for over 25 years. The latest version of Laura features control of the world's leading HPLC and radio detector systems to provide a single point of control for the entire radiochromatography analysis.

Laura™ also features;

  • Scalable solution from stand alone to enterprise level.
  • GLP and 21 CFR part 11 compliance options.
  • Unique summary table function for data comparison.
  • Document management system.
  • Automatic peak finder.
  • Powerful reporting and analysis tools.

Click Here for more information on Laura™

Is the Beta-RAM compatible with UHPLC?

Yes, the Beta-RAM has fittings, mixing components and a re-designed flow cell to reduce dead volume and retain peak shape when using low flow rates.

Can the Beta-RAM support fast update times?

Yes, the Beta-RAM can update the chromatogram up to 3 times per second to provide sufficient data points per peak even with the narrowest peaks.

Does the Beta-RAM have an integrated scintillant pump?

Yes, the B-RAM model 5B and 5C have an integrated scintillant pump that through the Laura software is capable of delivering scintillation cocktail from as low as 200ul per minute.

Can I use the Beta-RAM with a solid scintillator?

Yes, all the models of the Beta-RAM  will support the use of a flow cell packed with a solid scintillator. Calcium Fluoride, Yttrium silicate and silanized Lithium glass packed cells are available.

Is a range of flow cell sizes available?

Yes, flow cells can be provided in almost any size to suit users requirements from 5ul up to 1ml.

Can the Beta-RAM be installed vertically?

Yes, the Beta-RAM can be installed either vertically or horizontally to suit the available laboratory space.

Documents

Application Notes

  • Use of "High Sensitivity" Beta-Ram Radio Detector in Active Counting Mode

    Nejad H., Singh M., Ta C., Traversa E. APD/ER

    Download (3.55 MB)
  • Development of the Next Generation of On-line Radiochromatography Detectors

    T. Deakin and L. F. Thompson, Department of Physics and Astronomy, The University of Sheffield, and J. K. Clapham and R. A. Brown, LabLogic Systems Ltd.

    Download (777.01 kB)
  • Evaluation Of Active Counting Mode Option In LabLogic RAM Model 5 And Laura Software

    J. Attwood and B. O-Brien, AstraZeneca R&D Charnwood, and H. W. Loaring and A. Williams, LabLogic Systems Ltd.

    Download (1.44 MB)
  • Use Of Specific Radiolabelled Metabolite Standards In The Optimization Of Drug Metabolising Enzyme Assays

    Guy Webber, Richard Cole, Vicky Pope, Stephen Hollis, Serge D'Hainaut, Grant Johnston and Stuart Wood, BioDynamics Research Ltd.

    Download (410.87 kB)
  • Continuous Flow Measurment Of Radioactivity In HPLC Eluates

    Edward Rapkin Ph.D.

    Download (7.06 MB)
  • Microsomal Metabolism of the 5-Lipoxygenase Inhibitor L-739,010: Evidence of Furan Bioactivation

    Kanyin E. Zhang, Jeanne A. Naue, Byron Arison, Kamlesh P. Vyas

    Download (425.61 kB)
  • New Radio HPLC Detector Solves Old Problem

    Edward Rapkin, Ph.D.

    Download (377.98 kB)
  • "Comparison of heterogeneous and homogeneous radioactivity flow detectors for simultaneous profiling and LC-MS/MS characterization of metabolites"

    Egnash, Laura A. and Ramanathan, Ragu,, Journal of Pharmaceutical and Biomedical Analysis, 2002, pp. 271-284.

    Download (433.5 kB)

"The Disposition of Gemifloxacin, a New Fluoroquinolone Antibiotic, in Rats and Dogs "
J. V. Ramji, N. E. Austin, G. W. Boyle, M. H. Chalker, G. Duncan, A. J. Fairless, F. J. Hollis, D. F. McDonnell, T. J. Musick, and P. C. Shardlow. The American Society for Pharmacology and Experimental Therapeutics, Vol. 29, Issue 4, Part 1, 435-442, April 2001.

"Disposition and Metabolism of 2-(2"(1",3"-Dioxolan-2-Yl)-2-Methyl-4-(2'-Oxopyrrolidin-l -Yl)-6-Nitro-2h-l-Benzopyran(skp-450) in Rats"
Baek, Minsun, Chung. Hak Soon, Kim, Yunje, and Kim, Dong-Hyun. Drug Metabolism and Disposition Vol. 27. pp. 510-516.

"LC-MS/MS Characterization and comparison of metabolites formed from structural analogs. Cl-ABC, PD 123, and PD 456"
Egnash, Laura A., Lapham, Kimberly, and Ramanathan, Ragu, Pfizer Global. Research and Development, 2001.

"Sequential Injection Separation System with Stopped-Flow Radiometric Detection for Automated Analysis of 99Te in Nuclear Waste"
Egorov,Oleg, O'Hara, Matthew J., Ruzicka, Jaromir and Grate, Jay W.,, Analytical Chemistry. March 1, 1998, Vol. 70, No. 5, pp. 977-984.

"An efficient Synthesis of Carbon-14 Labelled Vigabatrin", Journal of Labelled Compounds and Radiopharmaceuticals"
Gill, Harpal S.,, VOL XXXVI. No. 5. 1994, pp. 425-430.

"Anaerobic Bioremediation of Benzene under Sulfate-Reducing Conditions in a Petroleum-Contaminated Aquifer"
Lovely. Derek R. and Anderson, Robert T., Environmental Science & Technology, 2000, Vol. 34, pp. 2261-2266.

"Basic Guide to the Mechanisms of Antiestrogen Action", Pharmacological Reviews"
MacGregor, Jennifer I., and Jordan, V.Craig , 1998, Vol. 50, pp. 151-196.

"Synthesis of Paclitaxel-C3'-14C". Journal of Labelled Compounds and Radiopharmaceuticals"
Walker. Donald G., Standridge, Robert T., and Swigor, John E., , 1994, Vol. XXXVI, No. 5, pp. 479-492.

"Beta -Particle Detection in HPLC by Flow-Through Monitoring vs. Liquid Scintillation Counting". Journal of Liquid Chromatography"
Rapkin. Edward, , 1993, 16(8), pp. 1769-1781.

"A Rapid Method for Determination of Beta-Emitting Radionuclides in Aqueous Samples"
Reboul, Scott H., and Fjeld, Robert A. , Radioactivity and Radiochemistry. 1994, Vol. 5, No. 3, pp. 42 - 49.

"Potential Effects of Surface Water Components on Actinide Determinations Conducted by Ion Chromatography"
Reboul, Scott H., and Fjeld, Robert A., Health Physics, April 1995, Vol. 68, No. 4, pp. 585-589.