Unsurpassed performance for PET metabolite profiling

Designed specifically for the detection and quantification of low-level PET metabolites in the presence of higher levels of a single substance, therapeutic agent, test compound, or substrate.

Posi-RAM™ utilizes two bismuth germanate (BGO) crystals mounted on matched photomultiplier tubes with a flow cell in between to achieve the highest possible sensitivity. Using fast coincidence electronics, an event is only registered when each of the detector assemblies detects an event within the coincidence resolving time.

The results are a low background and unmatched signal-to-noise ratio, enabling detection and quantification of low-level PET metabolites.

Applications…
The Posi-RAM is specifically designed for the detection and quantification of low level PET metabolites.

Flexibility…
Although the primary intended use is detection and quantification of low level PET metabolites, the Posi-RAM™ has been designed with flexibility in mind. The coincidence counting circuitry can be switched off to enable gross gamma counting. Under those settings, the Posi-RAM™ can be used for radiochemical purity checks.

Resolution and sensitivity…
To achieve the desired resolution and sensitivity, a range of high performance flow cells are available for the Posi-RAM™ with fixed volumes from 5 μL to 500 μL.

Controlled by Laura for PET™…
Posi-RAM™ control, digital data collection, analysis and reporting is provided by Laura for PET™, the industry standard radiochromatography data system developed by LabLogic.

Laura for PET

Posi-RAM control, digital data collection, analysis and reporting. All achieved using the industry standard radiochromatography data system Laura for PET.

Laura for PET has been the recognised industry standard software for radiochromatography for more than 20 years. The latest evolution of Laura for PET features control of many of the world's leading HPLC and radio detector systems to provide a single point of control for the entire radiochromatography analysis

Laura for PET also features:

  • Half-life correction.
  • Seamless interface with PETra™.
  • Scalable solution from stand-alone to enterprise level.
  • GLP and 21 CFR part 11 compliance options.
  • Automatic peak finder.
  • Document management system.
  • Unique summary table function for data comparison.
  • Powerful reporting and analysis tools.

Documents

Application Notes

Evaluation of a commercial radiochromatography module as an arterial blood activity monitor
C M Laymon, D Sashin, J P Carney, J Ruszkiewicz, D Altenburger, C R Becker, B J Lopresti, N S Mason, J M Mountz, J C Price, R Schavey and C A Mathis. Physics in Medicine and Biology 2008, Vol 53, No. 2, p339