The Hidex Sense is a compact, state-of-the-art, multi-mode microplate reader which provides a powerful and flexible platform for performing any kind of assay without limitations.
The Beta Plus version of the Sense uniquely combines liquid scintillation counting (LSC) with all common non-radiometric measurements, such as fluorescence and absorbance, into one very compact multi-mode microplate reader.
The dedicated PMT detector for LSC is also utilised to obtain ultra-high sensitivity luminescence for demanding applications and for reducing reagent use in assays such as dual luciferase. This option provides users with up to 10 times more sensitivity than other common luminescence microplate readers and scintillation counters.
Multi-Mode Microplate Reader Technology
The Hidex Sense microplate scintillation counter uniquely combines:
Fluorescence
Absorbance
Luminescence
Fluorescence Polarisation
TR – Fluorescence
FRET
TR-FRET
Dual Excitation Fluorescence
BRET
AlphaScreen® (optional)
High sensitivity luminescence (optional)
Liquid Scintillation Counting (optional)
Alternatively the Hidex Sense Beta model offers liquid scintillation counting and the functionality of a high sensitivity luminescence microplate reader only.
The compact size makes the Sense multi-mode microplate reader ideal for even the smallest laboratory and allows it to be easily adapted for robotic integration or situated within environmental control cabinets.
Unique Filter Arrangement
The innovative optical filter system can hold up to 32 optical filters, eliminating the need to change filters frequently. Filters are automatically identified by the software and can be used for both excitation and emission without any limitation.
Superior Performance
Sensitivity and Speed
Utilising filter technology for fluorescence applications not only gives optimal sensitivity but also faster reading speeds than other microplate readers.
Spectrograph as Standard
Protein quantification, enzyme activity and other photometric assays benefit from recording the full spectrum. Ultrafast spectrum readout is obtained in the Sense by using a high sensitivity spectrograph. The sample spectrum is scanned in less than a second, with no compromise to sensitivity.
Flexibility
Temperature Control
Temperature control is included as standard from ambient +2°C to 65°C.
Incubation and Shaking
The Hidex Sense multi-mode microplate reader allows linear, orbital and double orbital shaking with various intensities and user defined incubation periods.
Kinetics
The Hidex Sense multi-mode microplate reader is able to perform kinetic assays by plate or by well at user defined intervals. The kinetic profile is automatically plotted within the software.
It uniquely allows you to pause and resume kinetic runs, perfect for a multi-user environment.
Multiplexing
Multiple technologies can be performed sequentially allowing, for example, the ability to analyse multiple florescent dyes in one sample.
The software collate all results into one easy to handle excel file.
Optional
Automatic Dispensers
For the addition of reagents or kinetic measurements the Sense offers an optional one or two channel dispensing system. Injections can be performed either by well or by plate, for fast reactions or to maximise throughput.
Atmospheric Control Unit
A digitally controlled, high accuracy gas mixing system for cell viability, hypoxia and other cellular assays is available as an option. The CO2 and O2 concentrations are easily managed from the touchscreen.
Stacker
The Sense can be equipped with the Scorpion stacker for high throughput. There are options available such as light shields and a barcode reader. Watch the video below.
The Hidex Sense will help your lab become more efficient. Its extremely user friendly software – rated ‘Excellent’ on the System Usability Scale (SUS) – requires minimal training.
Comprehensive Assay Library
The software includes a comprehensive assay library and variety of data analysis tools for calculating a wide range of assay results from the multi-mode microplate reader.
Easy Export
Easy export of data to Excel, as well as the capability of importing and exporting templates makes the system ideal for multi-user environments.
User Friendly Interface
The touchscreen user interface is designed to make operation quick and simple. Application focused operation minimises time spent on instrument training and reading manuals.
Instant Access to your Assays
Favourite and recent assays are shown upfront on the screen, ready to run with a touch of your fingertip.
See our latest videos showcasing the Hidex Sense multi-mode microplate reader.
What type of microplates can it read?
1-1536 including PCR plates, cuvette adaptors and deep well.
Can I use a glove or mouse & keyboard with the touch screen?
Yes, the screen is touch and not heat sensitive so gloves can be used. Additionally you can use a mouse and keyboard if preferred.
How many filters are supplied?
10 filters are supplied that cover 80 - 90% of common assays, please discuss with our sales team if you require alternative filters. All filters can uniquely be used for excitation and emission. The microplate reader takes the standard sized filters which can be transferred from other instruments.
What filters are supplied?
300 nm, BW 80 nm
355 nm, BW 40 nm
460 nm, BW 25 nm
485 nm, BW 10 nm
535 nm, BW 20 nm
544 nm, BW 15 nm
575 nm, BW 20 nm
616 nm, BW 8.5 nm
620 nm, BW 10 nm
665 nm, BW 7.5 nm
Does the spectrograph detector cost extra?
No, the instrument comes with a spectrograph detector fitted as standard.
Do I need to supply the PC?
No, LabLogic supply the touchscreen PC and software with the instrument.
Can the instrument be supplied with a stacker for high throughput?
Yes, the Sense can be equipped with the Scorpion stacker for high throughput. There are options available such as light shields and a barcode reader. Watch the video below.
What about warranty and service?
The standard Hidex manufacturer warranty is one year.
Our service contracts cover all parts, labour, expenses and an annual preventative maintenance visit.
Can I trial the instrument?
Our product specialists bring the instrument to your site for one day to run your assays and compare results.
Click the tabs below to find out more about our customers and how they are using the Hidex Sense in their laboratories.
Louvain Institute of Biomolecular Science, France
Unveiling the regulatory network controlling natural transformation in lactococci
In a study by Frédéric Toussaint et al. at the Louvain Institute of Biomolecular Science in conjunction with IFF Health & Biosciences, the Hidex Sense multimode compact plate reader has been used to identify the physiological conditions that activate competence for DNA transformation in Lactococcus lactis, the most important lactococcal species.
The microplate reader was used to monitor the expression of the ComX gene through luminescence. Growth (OD600) and luciferase activity were monitored at 5-minute intervals on the reader for a maximum of 24 hours.
You can learn more about the study and how the Hidex Sense was used by clicking the button below.
Researchers from the Diabetes and Metabolism Group at Bristol Medical School chose the Hidex Sense multi-mode microplate reader to increase the throughput of luminescence assays as the group’s existing luminometer did not have stacking ability. The group were looking to match their current instruments impressive signal to background ratio for luminescence and therefore, the group chose the Hidex Sense. It ticked all boxes whilst offering additional capabilities such as TRF, absorbance and LSC which was useful for the group.
The group has been using the Hidex Sense microplate reader for assays using Nano-Glo® Luciferase. Nano-Glo® Luciferase assays allow researchers to detect the activities of firefly and luciferases in a single sample.
Congratulations to Jussi Hepojoki and his colleagues at the Department of Virology, the University of Helsinki for their excellent work on the development of a rapid PCR test for Covid-19 that uses a TR-FRET assay for SARS-CoV-2 performed on the Hidex Sense Multi-Mode Microplate Reader.
Jordan Pascoe is a first-year PhD student in the Faculty of Health and Medical Sciences at the University of Surrey. Jordan has been using the Hidex Sense multi-mode microplate reader to study antimicrobial resistance and how the metabolic state of bacteria may affect treatment efficacy, as part of wider research into tuberculosis.
By utilising filter technology for fluorescence, the Sense delivers optimal sensitivity and faster reading speeds than other monochromator-based microplate readers. It also features a spectrograph that can scan samples from 220-1000nm in less than a second, without compromising on sensitivity.
We spoke to Jordan to find out how he’s been using the Sense in his research.
Debbie Fischer and the Division of Pharmacy and Optometry at the University of Manchester are the new owners of the Hidex Sense microplate reader. Debbie is part of Kay Marshall’s research group investigating diagnostic biomarkers and improved therapies for female reproductive disorders.
Click the button below to find out what Debbie had to say.
Dr Brian Robertson, from Imperial College London’s Department of Medicine, is conducting vital research into creating a new vaccine for Tuberculosis (TB) using the Hidex Sense multi-mode microplate reader. The work is contributing towards the End TB Strategyfrom the World Health Organization (WHO).
Dr Brian Robertson is also a founding member of the MRC Centre for Molecular Bacteriology and Infection, and the Centre for Integrative Systems Biology and Bioinformatics. He is Co Editor-in-Chief of the journal Tuberculosis, and Director of the Wellcome Trust funded 4-year PhD programme in the Molecular and Cellular Basis of Infection.
The latest adopter of the Hidex Sense multi-mode microplate reader is Dan Bose, a Henry Dale Research Fellow at the University of Sheffield. Dan is part of the Sheffield Institute for Nucleonic Acids and the Department of Molecular Biology and Biotechnology, and his research focuses on the role of non-coding RNA’s in the cell and how they regulate gene expression.
The research in Dan’s department spans a range of disciplines, incorporating different aspects of biochemistry, molecular experimentation, to cell-based assays, and CRISPR gene editing.
The Hidex Sense multi-mode microplate reader is a compact, state-of-the-art instrument which maximises efficiency in your lab. It provides a powerful and versatile platform for performing any kind of assay across various application areas.
LabLogic recently caught up with the first ever UK customer, Dr Charles Brearley, from the University of East Anglia (UEA), to find out what he thought about the system.
Veteran Affairs Medical Center's (VAMCs) throughout the USA are fast selecting the Hidex range as their research instruments of choice including Cleveland, OH, Little Rock, AR, and San Juan, PR, read more here.
University of Leicester, UK
A research group at the University of Leicester has cited the Hidex Sense in several research papers on their successful development of novel formats of ''pseudo''-ELISA assays using nanoMIPs on the instrument. Read more about the paper here.
Brookhaven National Laboratory, USA
The Brookhaven National Laboratory has carried out a series of experiments using the Hidex Sense. Read more about the three-week long analysis here.
Utilizing Hidex Sense for mitochondrial and cytosolic calcium measurements using the luminescent calcium reporter protein aequorin and the fluorescent calcium indicator Fura-2 AM
The Sense has been used to study antimicrobial resistance in Mycobacterium tuberculosis at the Faculty of Health and Medical Sciences. Find out how here…
