Hidex Sense

Multi-Mode Microplate Reader

The Hidex Sense microplate scintillation counter uniquely combines:

• Fluorescence
• Absorbance
• Luminescence
• Fluorescence Polarisation
• TR – Fluorescence
• FRET
• TR-FRET
• Dual Excitation Fluorescence
• BRET
• AlphaScreen® (optional)
• High sensitivity luminescence (optional)
• Liquid Scintillation Counting (optional)

Alternatively the Hidex Sense Beta model offers liquid scintillation counting and the functionality of a high sensitivity luminescence microplate reader only.

Get a quote for the Hidex Sense today or contact us for either more information or to request a demo.

The compact size makes the Sense multi-mode microplate reader ideal for even the smallest laboratory and allows it to be easily adapted for robotic integration or situated within environmental control cabinets.

The innovative optical filter system can hold up to 32 optical filters, eliminating the need to change filters frequently. Filters are automatically identified by the software and can be used for both excitation and emission without any limitation.

Utilizing filter technology for fluorescence applications not only gives optimal sensitivity but also faster reading speeds than other microplate readers.

Protein quantification, enzyme activity and other photometric assays benefit from recording the full spectrum. Ultrafast spectrum readout is obtained in the Sense by using a high sensitivity spectrograph. The sample spectrum is scanned in less than a second, with no compromise to sensitivity.

Temperature control is included as standard from ambient +2°C to 65°C.

The Hidex Sense multi-mode microplate reader allows linear, orbital and double orbital shaking with various intensities and user defined incubation periods.

The Hidex Sense multi-mode microplate reader is able to perform kinetic assays by plate or by well at user defined intervals. The kinetic profile is automatically plotted within the software.

It uniquely allows you to pause and resume kinetic runs, perfect for a multi-user environment. 

Multiple technologies can be performed sequentially allowing, for example, the ability to analyze multiple florescent dyes in one sample.

The software collate all results into one easy to handle excel file. 

For the addition of reagents or kinetic measurements the Sense offers an optional one or two channel dispensing system. Injections can be performed either by well or by plate, for fast reactions or to maximize throughput.

A digitally controlled, high accuracy gas mixing system for cell viability, hypoxia and other cellular assays is available as an option. The CO2 and O2 concentrations are easily managed from the touchscreen.

The Sense can be equipped with the Scorpion stacker for high throughput. There are options available such as light shields and a barcode reader. Watch the video below.

The software includes a comprehensive assay library and variety of data analysis tools for calculating a wide range of assay results from the multi-mode microplate reader.

Easy export of data to Excel, as well as the capability of importing and exporting templates makes the system ideal for multi-user environments.

The touchscreen user interface is designed to make operation quick and simple. Application focused operation minimizes time spent on instrument training and reading manuals.

Favorite and recent assays are shown upfront on the screen, ready to run with a touch of your fingertip.

1-1536 including PCR plates, cuvette adaptors and deep well.

Yes, the screen is touch and not heat sensitive so gloves can be used. Additionally you can use a mouse and keyboard if preferred.

10 filters are supplied that cover 80 - 90% of common assays, please discuss with our sales team if you require alternative filters. All filters can uniquely be used for excitation and emission. The microplate reader takes the standard sized filters which can be transferred from other instruments.

• 300 nm, BW 80 nm
• 355 nm, BW 40 nm
• 460 nm, BW 25 nm
• 485 nm, BW 10 nm
• 535 nm, BW 20 nm
• 544 nm, BW 15 nm
• 575 nm, BW 20 nm
• 616 nm, BW 8.5 nm
• 620 nm, BW 10 nm
• 665 nm, BW 7.5 nm

No, LabLogic supply the touchscreen PC and software with the instrument.

Yes, the Sense can be equipped with the Scorpion stacker for high throughput. There are options available such as light shields and a barcode reader. Watch the video below.

The standard Hidex manufacturer warranty is one year.

Our service contracts cover all parts, labor, expenses and an annual preventative maintenance visit.

Our product specialists bring the instrument to your site for one day to run your assays and compare results.

Please contact us to arrange a visit.

Debbie Fischer and the Division of Pharmacy and Optometry at the University of Manchester are the new owners of the Hidex Sense microplate reader, click here to read about the work they are carrying out.

The Hidex Sense is used at Imperial College London for vital research into a new vaccine for Tuberculosis (TB) as part of the End TB Strategy from the World Health Organization (WHO), click here to read more it. 

The Hidex Sense is used in the Sheffield Institute for Nucleonic Acids and the Department of Molecular Biology and Biotechnology at the University of Sheffield, click here to read what Dan Bose, Henry Dale Research Fellow, had to say about the Sense.

The University of East Anglia (UEA) use the Hidex Sense for absorbance and fluorescence measurements, as well as fluorescence polarisation (FP), click here to read more.

Veteran Affairs Medical Center's (VAMCs) throughout the USA are fast selecting the Hidex range as their research instruments of choice including Cleveland, OH, Little Rock, AR, and San Juan, PR, read more here.

A research group at the University of Leicester has cited the Hidex Sense in several research papers on their successful development of novel formats of ''pseudo''-ELISA assays using nanoMIPs on the instrument. Read more about the paper here.

The Brookhaven National Laboratory has carried out a series of experiments using the Hidex Sense. Read more about the three-week long analysis here.

Studying antimicrobial resistance in Mycobacterium tuberculosis

Jordan Pascoe is a first-year PhD student in the Faculty of Health and Medical Sciences at the University of Surrey. Jordan has been using the Hidex Sense multi-mode microplate reader to study antimicrobial resistance and how the metabolic state of bacteria may affect treatment efficacy, as part of wider research into tuberculosis.

By utilizing filter technology for fluorescence, the Sense delivers optimal sensitivity and faster reading speeds than other monochromator-based microplate readers. It also features a spectrograph that can scan samples from 220-1000nm in less than a second, without compromising on sensitivity.

We spoke to Jordan to find out how he’s been using the Sense in his research.

Testing antibiotic efficacy

Jordan explained, “We use fluorescent reporters to observe bacterial growth and use broth microdilution to test different concentrations of antibiotics to see if the bacteria is being inhibited. This allows us to take a measure of antibiotic efficacy. It’s rudimentary work but it’s useful and important to further research we intend to do in the future.”

Working in a Containment Level 3 laboratory

Because Jordan’s research involves tuberculosis, the Hidex Sense is situated in the faculty’s Containment Level 3 laboratory (CL3). The Sense’s compact size allows it to be used inside environmental safety cabinets, and its innovative optical filter wheel can hold up to 32 optical filters, eliminating the need to change filters frequently.

Jordan said, “The Hidex Sense is situated in an MSC III cabinet with the infectious agent, so it’s handled and read in situ. I’ve used other plate readers in safety cabinets before, and the Hidex Sense is much more compact by comparison, which makes it a lot easier to use. As a plate reader, the Hidex is intuitive with everything where you would expect it to be, and its operation is straightforward.”